COVID-19 Vaccination and Obesity: Optimism and Challenges.
Identifieur interne : 000095 ( Main/Exploration ); précédent : 000094; suivant : 000096COVID-19 Vaccination and Obesity: Optimism and Challenges.
Auteurs : Matthew J. Townsend [États-Unis] ; Theodore K. Kyle [États-Unis] ; Fatima Cody Stanford [États-Unis]Source :
- Obesity (Silver Spring, Md.) [ 1930-739X ] ; 2021.
Abstract
Researchers have speculated that vaccines to prevent COVID-19 may be less effective for individuals with obesity, a major risk factor for mortality and morbidity from COVID-19. Initial results from the Pfizer-BioNTech and Moderna COVID-19 vaccine trials, though limited by inadequate power to compare subgroups and incomplete stratification of high-risk groups, appear to have similar efficacy among individuals with and without obesity. Careful follow up in placebo-controlled studies is required to generate data on long-term vaccine immunogenicity, particularly in high-risk groups. Subsequent analyses should stratify safety and efficacy results by each class of obesity. Speculation about variable effectiveness of COVID-19 vaccines in obesity likely increases vaccine hesitancy among individuals with obesity, who face not only a higher risk of severe outcomes from COVID-19 but also weight stigma which reduces healthcare engagement at baseline. Clinical and public health messaging must be data-driven, transparent, and sensitive to these biological and sociological vulnerabilities.
DOI: 10.1002/oby.23131
PubMed: 33506642
Affiliations:
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Initial results from the Pfizer-BioNTech and Moderna COVID-19 vaccine trials, though limited by inadequate power to compare subgroups and incomplete stratification of high-risk groups, appear to have similar efficacy among individuals with and without obesity. Careful follow up in placebo-controlled studies is required to generate data on long-term vaccine immunogenicity, particularly in high-risk groups. Subsequent analyses should stratify safety and efficacy results by each class of obesity. Speculation about variable effectiveness of COVID-19 vaccines in obesity likely increases vaccine hesitancy among individuals with obesity, who face not only a higher risk of severe outcomes from COVID-19 but also weight stigma which reduces healthcare engagement at baseline. 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Initial results from the Pfizer-BioNTech and Moderna COVID-19 vaccine trials, though limited by inadequate power to compare subgroups and incomplete stratification of high-risk groups, appear to have similar efficacy among individuals with and without obesity. Careful follow up in placebo-controlled studies is required to generate data on long-term vaccine immunogenicity, particularly in high-risk groups. Subsequent analyses should stratify safety and efficacy results by each class of obesity. Speculation about variable effectiveness of COVID-19 vaccines in obesity likely increases vaccine hesitancy among individuals with obesity, who face not only a higher risk of severe outcomes from COVID-19 but also weight stigma which reduces healthcare engagement at baseline. Clinical and public health messaging must be data-driven, transparent, and sensitive to these biological and sociological vulnerabilities.</AbstractText><CopyrightInformation>This article is protected by copyright. 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Townsend</name></region><name sortKey="Kyle, Theodore K" sort="Kyle, Theodore K" uniqKey="Kyle T" first="Theodore K" last="Kyle">Theodore K. Kyle</name><name sortKey="Stanford, Fatima Cody" sort="Stanford, Fatima Cody" uniqKey="Stanford F" first="Fatima Cody" last="Stanford">Fatima Cody Stanford</name><name sortKey="Stanford, Fatima Cody" sort="Stanford, Fatima Cody" uniqKey="Stanford F" first="Fatima Cody" last="Stanford">Fatima Cody Stanford</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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